Effect of erythrocytapheresis on arterial oxygen saturation and hemoglobin oxygen affinity in patients with sickle cell disease
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چکیده
منابع مشابه
The Effect of Controlled Breathing Exercises on Anxiety and Arterial Oxygen Saturation in Chronic Obstructive Pulmonary Disease
Introduction: Anxiety is one of the common symptoms and complications in patients with chronic obstructive pulmonary disease that increases readmission and decreases the quality of life in these patients. Objective: This study aimed to determine the effect of controlled breathing exercises on Anxiety and Arterial Oxygen Saturation in chronic obstructive pulmonary disease in the intensive care u...
متن کاملThe oxygen affinity of sickle hemoglobin.
The right-shifted oxyhemoglobin dissociation curve of sickle cell disease (SCD) has been thought to result in abnormally low arterial oxygen saturation (S(o)(2)), even when oxygen partial pressure (P(o)(2)) is normal. However, without polymer formation (minimal under normoxic conditions), HbS oxygen affinity is normal. We hypothesized that in SCD, in vivo S(o)(2) is normal when P(o)(2) is norma...
متن کاملClinical Implications of the Association of Fetal Hemoglobin with Peripheral Oxygen Saturation in Sickle Cell Disease
Article history: Received 3 September 2017 Accepted 3 September 2017 Available online 5 September 2017 inhibition of HbS polymerization—and therefore remain key topics of investigation and continued interest in the field. The current report by Nkya et al. (Nkya et al., 2017) shows associations between HbF, hemoglobin, pulse rate and systolic blood pressure with peripheral oxygen saturation in a...
متن کاملFetal Hemoglobin is Associated with Peripheral Oxygen Saturation in Sickle Cell Disease in Tanzania
Fetal hemoglobin (HbF) and peripheral hemoglobin oxygen saturation (SpO2) both predict clinical severity in sickle cell disease (SCD), while reticulocytosis is associated with vasculopathy, but there are few data on mechanisms. HbF, SpO2 and routine clinical and laboratory measures were available in a Tanzanian cohort of 1175 SCD individuals aged≥5years and the association with SpO2 (as respons...
متن کاملPolymerization of sickle cell hemoglobin at arterial oxygen saturation impairs erythrocyte deformability.
We have examined the filterability of sickle erythrocytes, using an initial-flow-rate method, to determine whether sufficient hemoglobin S polymer forms at arterial oxygen saturation to adversely affect erythrocyte deformability. The amount of intracellular polymer was calculated as a function of oxygen saturation to estimate the polymerization tendency for each of eight patients with sickle ce...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 1998
ISSN: 0361-8609,1096-8652
DOI: 10.1002/(sici)1096-8652(199809)59:1<5::aid-ajh2>3.3.co;2-6